Predictability and Inducibility of Detachment of Prostatic Central Gland Tissue after Prostatic Artery Embolization: Post Hoc Analysis of a Randomized Controlled Trial

Purpose

To assess the frequency and potential predictors of prostatic central gland tissue detachment (CGD), an enucleation-like reaction that sporadically occurred in a randomized controlled trial assessing efficacy and safety of prostatic artery embolization (PAE).

辨体-辨病-辨证诊疗模式在慢性病防治中的应用策略

依据中国防治慢性病中长期规划（2017-2025年），按照国医大师王琦教授倡导的"辨体-辨病-辨证诊疗模式"，提出慢性病"3+4+3"防治路向：面向三类人群（一般、高危、患病人群），朝向四种状态（无病、病前、病中、病后状态），指向三辨模式（辨体-辨病-辨证诊疗模式）。进而探讨其应用策略：对于一般人群无病状态——辨体养生，固本防病；对于高危人群病前状态——辨体干预，治本救萌；针对患病人群病中状态——"三辨"施治，标本兼顾；针对患病人群病后状态——辨体调理，固本防复。文中结合案例加以佐证，具有临床指导价值。     

复原通络方治疗下肢血栓性浅静脉炎的临床观察

[目的]观察复原通络方治疗瘀血阻络型下肢血栓性浅静脉炎的临床疗效。[方法]选取72例瘀血阻络型下肢血栓性浅静脉炎患者,随机分为对照组和治疗组各36例,对照组服用阿司匹林肠溶片每次1片,每日1次;治疗组同时加用复原通络方,每日1剂。观察时间为8周,比较用药前后两组患者的红肿、疼痛、色素沉着、条索状物等恢复情况及血液流变学相关指标的改变。[结果]治疗组的总有效率明显高于对照组,治疗组肿痛症状及血液流变学指标的改善也很明显(P0.05)。[结论]复原通络方在治疗瘀血阻络型下肢血栓性浅静脉炎时,具有良好的疗效。     

胫骨平台后外侧柱骨折手术患者发生切口感染的手术室相关因素及对策分析

目的探讨胫骨平台后外侧柱骨折手术患者发生切口感染的手术室相关因素及对策分析。方法选择2015年1月～2018年6月在我院治疗的胫骨平台后外侧柱骨折的患者383例的临床资料进行回顾性分析,根据术后是否发生切口感染分为感染组(n=36)与非感染组(n=347)。统计切口病原菌分布情况,分析影响患者术后切口感染手术室相关因素,并探讨预防对策。结果 36例患者共分离出病原菌48株。革兰阳性菌比例最高,占66.7%,其中金黄色葡萄球菌构成比最高,其次为表皮葡萄球菌。革兰阴性菌中铜绿假单胞菌是主要菌株,分离出1例真菌。多因素分析结果显示:急诊手术、有参观人员、接台手术、手术时间≥3 h是胫骨平台后外侧柱骨折患者术后切口感染的独立危险因素,而层流室是保护因素(P0.05)。结论胫骨平台后外侧柱骨折手术患者术后切口感染的手术室相关因素包括急诊手术、有参观人员、接台手术、手术时间≥3 h,应加强手术室相关管理,采取必要的措施,降低术后切口感染风险。     

The association between body mass index and in-hospital outcome among patients with acute myocardial infarction—Insights from China Acute Myocardial Infarction (CAMI) registry

BackgroundThe relationship between body mass index (BMI) and in-hospital mortality risk among patients with acute myocardial infarction (AMI) remains controversial.Methods and ResultsWe included 35,964 patients diagnosed with AMI in China Acute Myocardial Infarction registry between January 2013 and December 2016. Patients were categorized into 4 groups according to BMI level: BMI <18.5, 18.5–24.9, 25–30, and ≥30 kg/m² for underweight, normal, overweight, and obese groups, respectively. Clinical data were extracted for each patient, and multivariable logistic regression analysis was used to examine the association between BMI level and in-hospital mortality. Compared with normal-weight patients, obese patients were younger, more often current smokers, and more likely to have hypertension, hyperlipidemia, and diabetes. Multivariable regression analysis results demonstrated that compared with normal group, underweight group had significantly higher in-hospital mortality (odds ratio [OR]: 1.34; 95% confidence interval [CI]: 1.06–1.69; p = 0.016), while overweight group (OR: 0.86; 95% CI: 0.77–0.97; p = 0.011) and obese group (OR: 0.65; 95% CI: 0.46–0.91; p = 0.013) had lower mortality. All subgroups showed a trend toward lower in-hospital mortality risk as BMI increased.ConclusionsOur study provided robust evidence supporting “obesity paradox” in a contemporary large-scale cohort of patients with AMI and demonstrated that increased BMI was independently associated with lower in-hospital mortality.     

Investigation of the mechanisms of Genkwa Flos hepatotoxicity by a cell metabolomics strategy combined with serum pharmacology in HL-7702 liver cells

1. To investigate Genkwa Flos hepatotoxicity, a cell metabolomics strategy combined with serum pharmacology was performed on human HL-7702 liver cells in this study.

2. Firstly, cell viability and biochemical indicators were determined and the cell morphology was observed to confirm the cell injury and develop a cell hepatotoxicity model. Then, with the help of cell metabolomics based on UPLC-MS, the Genkwa Flos group samples were completely separated from the blank group samples in the score plots and seven upregulated as well as two down-regulated putative biomarkers in the loading plot were identified and confirmed. Besides, two signal molecules and four enzymes involved in biosynthesis pathway of lysophosphatidylcholine and the sphingosine kinase/sphingosine-1-phosphate pathway were determined to investigate the relationship between Genkwa Flos hepatotoxicity and these two classic pathways. Finally, the metabolic pathways related to specific biomarkers and two classic metabolic pathways were analyzed to explain the possible mechanism of Genkwa Flos hepatotoxicity.

3. Based on the results, lipid peroxidation and oxidative stress, phospholipase A₂/lysophosphatidylcholine pathway, the disturbance of sphingosine-1-phosphate metabolic profile centered on sphingosine kinase/sphingosine-1-phosphate pathway and fatty acid metabolism might be critical participators in the progression of liver injury induced by Genkwa Flos.     

Safety profile of the adjuvanted recombinant zoster vaccine: Pooled analysis of two large randomised phase 3 trials

Background

The ZOE-50 (NCT01165177) and ZOE-70 (NCT01165229) phase 3 clinical trials showed that the adjuvanted recombinant zoster vaccine (RZV) was ≥90% efficacious in preventing herpes zoster in adults. Here we present a comprehensive overview of the safety data from these studies.

Use of different combination diphtheria-tetanus-acellular pertussis vaccines does not increase risk of 30-day infant mortality. A population-based linkage cohort study using administrative data from the Australian Childhood Immunisation Register and the National Death Index.

Objective

To determine whether differences in combination DTaP vaccine types at 2, 4 and 6?months of age were associated with mortality (all-cause or non-specific), within 30?days of vaccination.